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Naoko Tokuda

Theoretical Biological Physics Laboratory
Sasai Group, Department of Applied Physics,
Graduate School of Engineering, Nagoya University
Furocho, Chikusa, Nagoya 464-8603, Japan
Room 473, South, building 3 of the School of Engineering
Phone: +81-52-789-5628
Fax: +81-52-789-3719
E-mail: tokuda@tbp.cse.nagoya-u.ac.jp

2000-2004@B.Sc. School of Science, Nagoya University
2004-2006@M.Sc. Department of Physics, Graduate School of Science, Nagoya University
2006-2012@Ph.D. Department of Computational Science and Engineering,
                         Graduate School of Engineering, Nagoya University
April 2012 - September 2012 Part-time lecturer, Meijo University
April 2012 - Present@Research fellow, Nagoya University

Research Statement:
Gene expression is controlled in a time and tissue-specific manner in a nucleus of
eukaryotic cells. In such a regulation, gene regulatory elements such as enhancers and
insulators have an important function. Recently, the three-dimensional structure of
DNA and chromosome in that function has been elucidated using the chromosome
conformation capture (3C)-based method. In addition, the three-dimensional structure
of all chromosomes, in other words the genome, in a yeast or human nucleus has been
inferred. However, it is not well understood how these structures and structure
fluctuations affect gene expression on a cell nucleus scale. We are approaching this problem
using a molecular modeling and simulation based on the physical properties of DNA and chromosome.

List of publications

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Page last updated: September 25, 2017