MICAN

A sequence-order independent protein structure alignment algorithm

About MICAN

MICAN is a protein structure alignment algorithm that can handle following situations

M) Multiple-chain complexes
I) Inverse direction of SSEs
C) Ca only models
A) Alternative alignments
N) Non-sequential alignments

The algorithm was designed so as to identify the best structural alignment between protein pairs by disregarding the connectivity between secondary structure elements (SSE). One of the key feature of the algorithm is utilizing the multiple vector representation for each SSE, which enables us to correctly treat bent or twisted nature of long SSE.

-Excutable binaries & source code are freely available at Download page.

Author

1. Shintaro Minami
   Department of Compuptational Science and Engineering, Nagoya Univ.
2. Kengo Sawada
   Department of Applied Physics, Nagoya Univ.
3. George Chikenji
   Department of Computational Science and Engineering, Nagoya Univ.

Reference

1. MICAN : a protein structure alignment algorithm that can handle Multiple-chains, Inverse alignments, Ca only models, Alternative alignments, and Non-sequential alignments.
   Shintaro Minami, Kengo Sawada and George Chikenji,
   BMC Bioinformatics 2013, 14(1):24.

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